Abstract
Changes in the pH of interstitial fluid were measured with H +-selective double-barreled micropipette electrodes in fascia dentata of urethane-anesthetized rats. Paroxysmal afterdischarges provoked by repetitive stimulation of an afferent fiber tract brought in their wake acidification by 0.07 to 0.2 pH units. Spreading depression caused acidification by 0.2–0.5 pH units. Acid shifts were often preceded by transient alkalinization. Acidification is attributed to the production of CO 2 and of other acid metabolites.
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