Abstract

The enantiomers of 2-fluoro-2-phenyl propanoic acid have been separated and theirabsolute configurations determined: the specific rotation of the acid with an R configurationis [α] 20 D= −28.5° ( c = 1.5, ethanol). This acid has been used as a chiral derivatizingagent. Esters and amides prepared from this acid and chiral alcohols or amines presentimportant fluorine chemical shift differences between the diastereoisomers

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