Abstract
The influence of the chronic arterial carbon dioxide tension on the acid-base response to acute change in arterial carbon dioxide tension was studied in patients with chronic obstructive pulmonary disease. Acute changes in arterial carbon dioxide tension were produced experimentally by having the patients breathe various mixtures of carbon dioxide in air and by hyperventilation. Acute changes in arterial carbon dioxide tension occurred clinically during oxygen-induced hypoventilation, followed by ventilator therapy. The acute acid-base response was expressed as the ratio of change in arterial hydrogen ion concentration to change in arterial carbon dioxide tension. This ratio was inversely and linearly related to chronic values of arterial carbon dioxide tension and plasma bicarbonate concentration. The more efficient buffering of acute changes in carbon dioxide tension in patients with chronic obstructive pulmonary disease with hypercapnia was attributed both to high chronic bicarbonate concentrations and...
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