Abstract
THE USE OF hypothermia to reduce metabolism has introduced new problems in the acid-base field. Since induced hypothermia necessitates artificial ventilation of the patients, knowledge of the correct P co 2 and pH at which to maintain these patients is essential. This calls for determinations of blood pH and P co 2 in hypothermic patients. As a result methodological and theoretical problems have arisen. How should these measurements be carried out? At the usual measuring temperature (37 C or 38 C), or at the temperature of the patient, or at both temperatures? In any case it is necessary to know how the change of temperature itself affects the pH and P co 2 of the blood. In this paper we will discuss physicochemical and methodological problems of pH and P co 2 measurements at different temperatures as well as some physiological problems. Physicochemical and Methodological Problems The acid-base changes of plasma and whole blood with temperature are caused
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