Abstract

The effect of equitoxic doses of three carbamate local anesthetics (pentacaine, carbisocaine and heptacaine), and a derivative of lidocaine (trimecaine) on the acid-base balance of blood was studied in conscious rabbits. In addition, changes in arterial blood pH induced by local anesthetics in relation to lipophilicity of the respective drugs were evaluated. All the drugs administered at the dose of half of LD50 induced a significant decrease in the arterial blood pH as well as in the plasma bicarbonate level and in the blood base excess. The observed acidosis was compensated within a 60 minute period by hyperventilation. The local anesthetic-induced decrease in the blood pH, expressed as AUC, correlated to some extent with the partition coefficient of these agents. These findings suggest that the acidifying effect of local anesthetics may be dependent on their lipophilicity.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.