Abstract
OPINION article Front. Physiol., 07 September 2021 | https://doi.org/10.3389/fphys.2021.734418
Highlights
Glioblastoma multiform (GBM), referred to as glioblastoma, is the most common malignant tumor in the brain, known for its resistance to therapeutic agents and poor prognosis (Shergalis et al, 2018)
The impact of acid-sensing ion channels (ASICs), ASIC1, in glial cell lines is being further investigated in efforts to reduce glial cell migration, study the potential proliferation effects, and to understand how ASIC1 inhibitors can regulate apoptosis of glioma cells (Sun et al, 2013; Tian et al, 2017)
A recent study from Dr Xiong’s laboratory published in the American Journal of Cancer Research described a combination of wet-lab techniques, including whole-cell patch-clamp recording, Western blotting, cell viability assay, wound-healing assay and trans-well migration assay, that were used to determine if the activation of ASIC1 by a weak acid had a correlation with the migration and proliferation of glial cell lines U87MG and A172 (Sheng et al, 2021)
Summary
Glioblastoma multiform (GBM), referred to as glioblastoma, is the most common malignant tumor in the brain, known for its resistance to therapeutic agents and poor prognosis (Shergalis et al, 2018). The impact of ASICs, ASIC1, in glial cell lines is being further investigated in efforts to reduce glial cell migration, study the potential proliferation effects, and to understand how ASIC1 inhibitors can regulate apoptosis of glioma cells (Sun et al, 2013; Tian et al, 2017).
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