Abstract

1. 1. A comparative study of multiple forms of acid phosphatase (AcPase) in various organs of mammals was carried out. 2. 2. These studies indicated that the high-molecular weight AcPase is preferentially expressed by tissues which undergo cell proliferation such as epithelial tissues; on the contrary, the low-molecular weight enzyme seems to be characteristic of highly differentiated tissues such as nervous, muscle and blood erythrocytes. 3. 3. The existence of a new AcPase activated by Zn 2+ ions was observed in all tissues studied with the exception of erythrocytes. 4. 4. The enzyme shows a molecular weight of 57 kDa, is insensitivie to NaF, hydrolyzes p-nitrophenylphosphate and o- c-phenylphosphate; ATP, o-naphthylphosphate and β-glycerolphosphate are also dephosphorylated.

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