Abstract
ACID phosphatase and cathepsin are two of the hydrolytic enzymes shown by de Duve1 to be present in the lysosomal fraction of liver, and similar particles have been shown in many other tissues2. Increases in lysosomal enzymes have been shown to be present in cases of rapid tissue breakdown3,4. The synovial tissue in a rheumatoid arthritic patient may proliferate rapidly, forming many villi. and can extend as the so-called pannus tissue growing over the articular cartilage. When this pannus tissue forms, erosion of the cartilage takes place. An increase in enzymes of the lysosomal type might therefore be expected in rheumatoid tissue.
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