Abstract
Medicinal plants have been representing a rich source of antimicrobial agent as well as can be used as antacid in various ayurvedic preparations. Hence the present study was undertaken to evaluate the antibacterial potential and antacid properties of selected six plant extracts. The plant extracts such as Methanolic extracts of Cassia tora (MECT), Methanolic extracts of Pithecellobium dulce (MEPD), Chloroform extracts of Butea monosperma (CEBM), Butanolic extracts of Pongamia pinnata (BEPP), Water extracts of Tephrosia purpurea (WETP), Methanolic extracts of Mucuna pruriens (MEMP) were selected for the study. The neutralization capacity in vitro was performed using the titration method of Fordtran’s model. The antimicrobial activity was performed by using the disc diffusion method and minimum inhibitory concentration was determined by broth dilution method. The consumed volumes of artificial gastric juices to titrate to pH 3.0 for water, Sodium bicarbonate, MECT, MEPD, CEBM, BEPP, WETP and MEMP extracts solutions were found to be 1.3±0.02, 34.22±0.59*, 8.26±0.08*, 10.58±0.09*, 9.6±0.1*, 7.35±0.05, 9.36±0.09* and 9.88±0.06* respectively. The highest activity of plant extract has been shown in MECT and was found to be 25.00 mm diameter of zone of inhibition against E. coli at the concentration of 250 μg/disc followed by 24.00 mm diameter of zone of inhibition against P. aeruginosa at concentration of 250 μg/disc. Against Gram positive organism, the MECT and MEPD possess 21.00 mm and 20.00 mm diameter of zone of inhibition respectively against M. Lutues at concentration of 250μg/disc. The MIC values were found in the range of 50-500μg/ml against the tested organisms. The acid neutralizing capacity was found to be higher in MEPD and MEMP extracts among all the selected extract. The highest in vitro antimicrobial activity was found in MECT extract against gram-negative and gram-positive bacteria.
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