Abstract
Recent work on the blood chemistry of dogs and cats suffering from adrenal insufficiency suggests the probability that the adrenal cortex secretes a hormone which in some manner controls the normal functioning of the kidney. Several investigators1 report marked nitrogen retention following adrenal removal. Swingle2 and Swingle and Eisenmann3 demonstrated phosphorus retention, and the existence of an uncompensated non-volatile acidosis in severe adrenal insufficiency. The acidosis was considered to be due to retention of the acid end products of normal metabolism.Owing to the difficulty of bleeding cats repeatedly, and the fact that considerable quantities of blood are necessary for analysis, the writer made a detailed investigation of the acid intoxication following adrenal removal in dogs.Adult male and non-pregnant dogs were employed, an interval of 5 to 10 days elapsing between operations. Longer intervals were not found to prolong the survival period, the average survival period to date being 5½ to 6 ...
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