Abstract
Gastroesophageal reflux disease and Barrett esophagus are identifiable risk factors for esophageal adenocarcinoma. In a recent report, researchers noted that pulsed-acid exposure facilitates expression of NOX5, which is an NADPH-oxidase catalytic subunit and a major isoform of the NADPH-oxidase that is present in BE esophageal adenocarcinoma cells and tissues with high-grade dysplasia (Journal Watch Gastroenterology Dec 1 2006). Furthermore, in that study, the levels of acid-induced NOX5 expression …
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