Abstract
The in vitro release of timolol maleate from poly(ortho ester) matrices was studied. Release profiles ranged from simple zero-order to complex multiphasic release patterns. The observed profile was dependent on both the polymer and the catalyst selected. Polymers that contained ⩾ 50 mol% ofcyclohexane-trans-1,4-dimethanol (CDM) in the backbone consistently gave linear drug release profiles. Multiphasic drug release profiles were associated with polymers of < 50 mol% of CDM and lipophilic acid catalysts. The nature of the drug release profile was related to the Tgof the polymer-drug-catalyst composite. A purely surface or bulk erosion-controlled drug release mechanism could not account for the observed drug release profiles. Linear release from devices of varied geometries suggested that diffusion through a rate controlling surface skin layer may be a limiting step in the overall drug release mechanism.
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