Abstract
AbstractAcid catalyzed multicomponent reaction (MCR) for the synthesis of N‐benzhydryl amide derivatives from aldehydes, N,N‐disubstituted arylamines and nitriles is reported. The reaction is compatible with electronically differentiating aryl/heteroaryl aldehydes/acetals, different nucleophiles (cyclic and acyclic N,N‐disubstituted arylamines,β‐naphthols, 1,3 dicarbonyl, 1,3,5‐trimethoxy benzene), alkyl nitriles, aryl/heteroaryl nitriles in catalytic TFA/TfOH through tandem Ritter reaction. The one‐pot MCR with broad substrate scope generated a wide variety of sterically hindered N‐substituted amides and is successfully applied for the synthesis of isoindolinone.
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