Abstract
The constants and thermodynamic characteristics of the acid-base equilibrium between the first synthesized 6-methyluracil derivative with a 1,2,3-triazole ring at the C(5) atom of the uracil ring—5-(1-pentyl-4-methyl-1,2,3-triazol-4-yl)-6-methyluracil (1)—and its model compound 5,6-dimethyluracil were determined by potentiometric titration in aqueous solutions. It was shown that the 1,2,3-triazole ring does not significantly affect the acid-base properties of the uracil fragment in compound 1. The deprotonation sites of compound 1 in aqueous alkaline and DMSO solutions were suggested. The structure of compound 1 was proved by NMR and IR spectroscopy and elemental analysis.
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