Abstract
Lymphoma is a hematopoietic neoplasm commonly diagnosed in dogs. Its etiology is still unknown and is probably multifactorial. It happens mainly in middle-aged animals or elderly people with no racial predilection. In Veterinary Medicine the most common classification of lymphoma is based on the anatomical location of the tumor masses, such as, multicenter, mediastinal, alimentary and extranodal. The latter is characterized as the appearance of an isolated lymphoid tumor in any organ not belonging to the primary or secondary lymphoid tissue. Other common locations include the nervous system, heart, eyes, nasopharynx, bones, testicles, urinary bladder, and penis. The clinical signs of this neoplasm are varied and depend on its anatomical location. For the definitive diagnosis it is necessary to perform the histopathological or cytological evaluation of the affected tissues, however, the accomplishment of complementary tests is necessary for clinical staging. Polychemotherapy is the most widely used and effective treatment in dogs with lymphoma and dozens of protocols are available. The steps of chemotherapy are induction of remission, maintenance of remission, and re-induction of remission or rescue therapy. The objective of this work was to describe the postmortem anatomopathological findings of large cell lymphoma in a 3-year-old Chow Chow canine, in order to contribute to further studies about this neoplasm.
Highlights
Lymphoma is a hematopoietic neoplasm commonly diagnosed in dogs
The objective of this work was to describe the postmortem anatomopathological findings of large cell lymphoma in a 3-year-old Chow Chow canine, in order to contribute to further studies about this neoplasm
Se objetivó con este trabajo describir los hallazgos anatomopatológico post mortem del linfoma de células grandes en un canino, de la raza Chow Chow con edad de 3 años, para contribuir a posteriores estudios acerca de esta neoplasia
Summary
Foi atendido em uma clínica veterinária um canino, sexo masculino, de três anos de idade, raça Chow Chow, com queixa clínica de intolerância ao exercício, anorexia, apático, prostração e perda dos movimentos dos membros posteriores. Foram solicitado exame de rotina e complementares como hemograma, ultrassonografia abdominal, bioquímico renal e hepático e Snap 4dx Test. Foram coletados materiais como fígado, rins, coração e testículos, fixados em formaldeído 10% para avaliação histopatológica. Após o óbito do paciente, foi realizado à necropsia e coletado órgãos como o fígado (Figura 1), rins (Figura 2), coração (Figura 3) e testículos (Figura 4). Macroscopicamente o fígado apresentava regiões com coloração enegrecida e amarronzadas e a vesícula biliar estava repleta. Fígado de um canino da raça Chow Chow diagnosticado com linfoma de células grandes. No exame de ultrassonografia abdominal foi identificado hepatomegalia importante, com presença de lesões em parênquima hepático que tinha neoplasia como principal diagnostico diferencial. Rins de um canino da raça Chow Figura 3.
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