Acetylsalicylic acid resistance in patients with acute ischemic stroke

Abstract

This paper investigates the sensitivity to aspirin in patients with ischemic stroke in the early recovery period by optical aggregometry. The obtained results revealed individuals insensitive to aspirin. The aim is to detect the incidence of biochemical aspirin resistance among patients with history of ischemic stroke on the background of aspirin. Material and methods. Clinical and laboratory analysis of 80 patients with acute ischemic stroke who received 75 mg of acetylsalicylic acid (ASA) before bedtime as a preventive measure. Sensitivity to aspirin was determined by optical aggregatometry with adrenaline inducer. With an increase in optical permeability above 60%, aspirin resistance was ascertained. Results. It was found that among the surveyed patients, 20 (25%) were aspirin resistant, that is, the use of ASA for the purpose of secondary prevention in them will not prevent the recurrence of a vascular catastrophe. Conclusions. Monitoring the state of platelet link using optical aggregatometry allows timely to detect the lack of response to ASA and necessitates correction of the applied antiplatelet therapy.