Acetylpanaxydol and panaxydolchlorohydrin, two new polyenes from Korean ginseng with cytotoxic activity against L1210 cells

Abstract

Two new polyines showing good cytotoxic activity against L1210 cells were isolated from Korean ginseng root. These were 3-acetyloxy-9,10-epoxy-heptadec-1-en-4,6-diyne(acet ylpanaxydol, ED50 = 0.52 microgram/ml) and 10-chloro-3,9-dihydroxyheptadec-1-en-4,6-diyne(Panaxydolc hlorohydrin, ED50 = 0.50 microgram/ml).