Abstract
An electrochemical sensor for simultaneous determination of the tryptamines, serotonin (ST) and melatonin (MT) has been developed based on immobilizing acetylene black nanoparticles-chitosan (AB-C) on gold electrode. AB-C exhibited remarkable electro-catalytic activity and enabled effective resolution as well as simultaneous determination of ST and MT under optimal conditions. The electro-catalytic response of the sensor was proportional to the tryptamine concentration in the range 5.0 × 10−7 M to 1.0 × 10−4 M and 2.0 × 10−5 M to 4.5 × 10−4 M with limits of detection 1.6 × 10−7 M and 1.9 × 10−6 M for ST and MT, respectively. Different kinetic parameters, such as diffusion coefficient and heterogeneous rate constant, were also determined by making use of different techniques such as chronoamperometry and linear sweep voltammetry. The developed sensor was successfully applied for the quantification of ST and MT in biological sample.
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