Abstract
Acetylcholine reverses the inhibitory action of a high potassium ion concentration on glycine uptake into rat brain cortex slices incubated in a physiological Ringer–glucose medium. The effect of acetylcholine, which may take place at 0.02 mM, is enhanced by the presence of eserine which itself is without effect. Choline and hemicholinium at equivalent concentrations are also without effect. The reversing action of acetylcholine is specific, as it cannot reverse the inhibitory action of ammonium ions, ouabain, L-glutamate, or L-glutamine on glycine transport into the brain. As the presence of acetylcholine does not affect the ATP level, it is suggested that it acts by promoting the influx of sodium ions, which have a controlling effect on the amino acid influx.
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