Abstract
CAESIUM depolarization of muscle membrane is further increased when choline is added to the bathing caesium–Ringer solution1,2. This caesium–choline depolarization remains constant in the continued presence of caesium, even when choline is removed from the Ringer. When caesium is replaced by potassium following removal of choline, the caesium–choline effect is reversed and the normal resting membrane potential is recovered2. It appears that choline reacts in specific fashion with membrane ‘receptors’, the result of this reaction depending on caesium and potassium ions; in the presence of caesium, a depolarization results; in the presence of potassium, none. Scanning data show that when muscles are treated with caesium–Ringer, the entire muscle surface becomes sensitive to choline. The work presented here was designed to elucidate the action of acetylcholine (ACh) on the caesium-treated muscle membrane, in comparison with the action of choline (Ch) previously described, and to determine whether: (1) an additional depolarization is evoked only when caesium is added before acetylcholine; (2) D-tubocurarine and eserine have any effect on the additional depolarization produced by ACh.
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