Abstract
In experiments on 1, 8–10 and 26–28 months old white rats there were determined: the intensity of acetylcholine formation in isolated atria (Vlk and Tuček, 1964); choline acetylase (EC 2.3.1.6.) activity (Hebb and Waites, 1956; Tuček, 1964) in heart, sciatic nerve and m.gastrocnemius; acetylcholinesterase (EC 3.1.1.7.) and non specific cholinesterase (EC 3.1.1.8.) activity (Vlk and Tuček, 1961) in heart, m.gastrocnemius and intestine. The intentine of acetylcholine formation in isolated atria was decreased with aging. Choline acetylase activity in atria and sciatic nerve was increased at the period of growth but in old rats it was significantly decreased. A considerable drop of choline acetylase activity was found in skeletal muscle of adult rats as compared with 1 month old animals. It remained unchanged in the muscles of old rats. With aging the intensity of acetylcholine hydrolysis decreased in the variuus parts of the heart and skeletal muscle, but did not change in intestine. In atria of old rats, the activity of the non specific cardiac cholinesterase rats was at the same high level as in adults, while in the other parts of heart its activity was gradually decreased with aging. The activity of the skeletal muscles acetylcholinesterase was decreased with aging. Age-conditioned changes in acetylcholine metabolism play an important role in weakening nervous influences upon the tissues and increase their sensitivity to the humoral factors in aging.
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