Abstract
The electrophysiological property of acetylcholine (ACh)-induced current ( I ACh) was studied in paratracheal ganglion cells freshly isolated from rat trachea under whole-cell voltage-clamp condition. I ACh consisted of an initial transient peak component and a successive steady-state plateau one. The peak compenent increased in a sigmoidal fashion with increasing ACh concentration. The I ACh was mimicked by nicotine. The current-voltage relationship for the I ACh inward rectification at the positive membrane potentials beyond the reversal potential ( E ACh). In a K +-free solution, the E ACh was close to the Na + equilibrium potential. The I ACh was blocked by either d-tubocurarine or atropine. The ion selectivity of ACh-activated channels to various monovalent cations was weak, and similar to those of other preparations. It was concluded that the I ACh in rat paratracheal ganglion cells was mediated by nicotonic receptor activation.
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