Abstract
Cyclin-dependent kinase 5 (CDK-5) appears to play a significant role in peripheral nerve regeneration as CDK-5 inhibition retards nerve regeneration following nerve crush. Anti-inflammatory drug acetyl salicylic acid elevates CDK-5 and reduces ischemia – reperfusion injury in cultured neurons. In this study we have evaluated the effect of acetyl salicylic acid on functional recovery following sciatic nerve crush in mice. Eighteen Swiss albino mice underwent unilateral sciatic nerve crush. Test animals received acetyl salicylic acid (100 mg/kg/day, n = 6 or 50 mg/kg/day, n = 6) and control animals (n = 6) received normal saline for 14 days following surgery. Functional recovery was assessed with improvement in Sciatic Function Index, nociception and gait. In comparison with normal saline treatment, acetyl salicylic acid (100 mg/kg/day) significantly improved functional recovery following sciatic nerve crush. Anti-inflammatory drug acetyl salicylic acid appears to be a promising agent for treating peripheral nerve injuries and hence elucidation of its neuroprotective pathways is necessary.
Highlights
The injured adult mammalian peripheral nerves, in contrast with axons injured inside central nerve tracts, show vigorous regeneration [1]
In addition to the induction of transcription factors, adhesion molecules, growth associated proteins and structural components required for axonal elongation, intracellular signalling molecules that control cell cycle and differentiation appears to play a major role in nerve regeneration process [1]
In this study we have evaluated the effect of acetyl salicylic acid (ASA) at two doses (100 mg/kg/day and 50 mg/kg/day) on functional recovery following peripheral nerve injury using mouse sciatic nerve crush model
Summary
The injured adult mammalian peripheral nerves, in contrast with axons injured inside central nerve tracts, show vigorous regeneration [1]. In this study we have evaluated the effect of ASA at two doses (100 mg/kg/day and 50 mg/kg/day) on functional recovery following peripheral nerve injury using mouse sciatic nerve crush model. For sham controls the sciatic nerve of the right hind limb was surgically exposed but no crush was made.
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