Abstract
The effects of acetyl- l-carnitine on cerebral glucose metabolism were investigated in rats injected with differently 14 C - and 13 C -labelled glucose and sacrificed after 15, 30, 45, and 60 min. Acetyl- l-carnitine was found to reduce total 14 CO 2 release from [ U- 14 C ]glucose along with the decrease in [ 1- 13 C ]glucose incorporation into cerebral amino acids and tricarboxylic acid cycle intermediates. However the 13 C labelling pattern within different carbon positions of glutamate, glutamine, GABA, and aspartate was unaffected by acetyl- l-carnitine administration. Furthermore, the cerebral levels of newly-synthesized proglycogen were higher in rats treated with acetyl- l-carnitine than in untreated ones. These results suggest that acetyl- l-carnitine was able to modulate cerebral glucose utilization and provide new insights on the mechanisms of action of this molecule in the central nervous system.
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