Abstract
abstract Acetyl hexapeptide-3 has been used in anti-aging topical formulations aimed at improving skin appearance. However, few basic studies address its effects on epidermis and dermis, when vehiculated in topical formulations. Thus, the objective of this study was to determine the clinical efficacy of acetyl hexapeptide-3 using biophysical techniques. For this purpose, formulations with and without acetyl hexapeptide-3 were applied to the ventral forearm and the face area of forty female volunteers. Skin conditions were evaluated after 2 and 4-week long daily applications, by analyzing the stratum corneum water content and the skin mechanical properties, using three instruments, the Corneometer(r) CM 825, CutometerSEM 575 and ReviscometerRV600. All formulations tested increased the stratum corneum water content in the face region, which remained constant until the end of the study. In contrast, only formulations containing acetyl hexapeptide-3 exhibit a significant effect on mechanical properties, by decreasing the anisotropy of the face skin. No significant effects were observed in viscoelasticity parameters. In conclusion, the effects of acetyl hexapeptide-3 on the anisotropy of face skin characterize the compound as an effective ingredient for improving conditions of the cutaneous tissue, when used in anti-aging cosmetic formulations.
Highlights
In recent decades, cosmetic formulations have been developed and employed in the treatment or prevention of skin changes resulting from aging, such as loss of elasticity, dryness, formation of wrinkles and spots, possible delaying invasive procedures such as plastic surgery
The aim of this study was to determine the real benefits of acetyl hexapeptide-3 on human skin, by analyzing the effects of a cosmetic formulation containing this active substance in terms of stratum corneum water content and skin mechanical properties
Acetyl hexapeptide-3 has been used in anti-aging topical formulations due to its effects in improving the skin appearance (Blanes-Mira et al, 2002; Zhang, Falla, 2009)
Summary
Cosmetic formulations have been developed and employed in the treatment or prevention of skin changes resulting from aging, such as loss of elasticity, dryness, formation of wrinkles and spots, possible delaying invasive procedures such as plastic surgery In this context, substances with anti-aging action have been proposed to delay the appearance of wrinkles or leaving them less visible. The skin is a neuroendocrine immune organ in which many different molecules operate in an autocrine-paracrine manner to guarantee tissue homeostatsis in physiological and pathophysiological condition (Sivilia et al, 2008; Takema et al, 1994) Due to their chemical structure, peptides may act in the hydration, skin protection and homeostasis, keeping cutaneous tissue healthy and with a young appearance
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