Abstract
Three triterpenoid alkaloids, buxakashmiramine [(20 S)-20-dimethylamino-4′,6′-dimethoxy-5′-hydroxybenzoylamino-3β-methyl-buxan-31-ol] ( 1 ), buxakarachiamine [(20 S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-butanoylamino-9,10- seco-buxa-9(11), 10(19)-dien-31-ol] ( 2 ) and buxahejramine [(20 S)-20-dimethylamino-2′-hydroxy-3β-methyl-3′-methyl-pentanoylamino-9,10- seco-buxa-9(11), 10(19)-dien-31-ol] ( 3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C ( 4), cyclovirobuxeine-A ( 5), cyclomicrophylline-A ( 6) and semperviraminol ( 7) were isolated for the first time from this species. Their structures were established through extensive spectroscopic studies. Most of these compounds exhibited anticholinesterase activity.
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