Abstract
Acetone-2-C14 was injected intravenously into two spontaneously ketotic cows and one cow fasted for five days, and into all three cows when lactating normally. Peaks in specific activity of respired CO2 and plasma glucose occurred 2 hr later. The standardized specific activity was higher in lactose than in casein or milk fat in all cows, for both the normal and ketotic states. Although the pattern of distribution of C14 among the various products was the same in normal and ketotic cows, the over-all recovery of C14 was only about one-tenth as great in ketotic cows as in normal cows. The data are consistent with acetone metabolism being predominantly glucogenic but quantitatively unimportant in both normal and ketotic cows.
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