Abstract
AbstractBlood acetoin concentrations in rabbits were followed after administration of ethanol to animals receiving disulfiram and to control animals. Disulfiram increased blood acetoin before and after the administration of alcohol. No increase was observed in animals receiving alcohol alone. Acetoin formation from acetaldehyde and pyruvate or ethanol and pyruvate was investigated in vitro. In liver homogenates and minced liver acetoin was formed from ethanol and pyruvate, but not from ehtanol or pyruvate alone. Disulfiram inhibited acetoin synthesis from theanol and pyruvate under aerobic conditions, but not anaerobically or when acetaldehyde and pyruvate were used as substrates. The role of acetoinin alcohol metabolism and disulfiramalcohol reaction is discussed.
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