Abstract
By covalently modifying Hsp70.1 with dual functions of recycling damaged/aged proteins and stabilizing the lysosomal membrane, ‘hydroxynonenal’, which derive from ω-6 polyunsaturated fatty acid-rich vegetable oils (exogenous), and from membrane phospholipids and low density lipoprotein (intrinsic), may play crucial roles in the occurrence of Alzheimer’s neuronal death. Aldehyde dehydrogenase is known to participate in the removal of not only ethanol-derived acetaldehyde, but also ω-6 fatty acid-derived ‘hydroxynonenal’. Here, using acetic acid bacteria as supplements with the enzyme activity of aldehyde dehydrogenase, the author perspectively reviews the most reliable preventative strategy for Alzheimer’s disease.
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