Abstract
The capability of graphene-based biosensors used to detect biomolecules, such as DNA and cancer marker, is enormously affected by the quality of graphene. In this work, high quality and cleanness graphene were obtained by CVD based on acetic acid (AA) and ammonium persulfate (AP) pretreated copper foil substrate. Hall effect devices were made by three kinds of graphene which were fabricated by CVD using no-treated copper foil, AA pre-treated copper foil and AP pre-treated copper foil. Hall effect devices made of AA pre-treated copper foil CVD graphene and AP pre-treated copper foil CVD graphene can both enhance the sensitivity of graphene-based biosensors for DNA recognition, but the AA pre-treated copper foil CVD graphene improves more (≈4 times). This may be related to the secondary oxidation of AP pre-treated copper foil in the air due to the strong corrosion of ammonium persulfate, which leads to the quality decrease of graphene comparing to acetic acid. Our research provides an efficient method to improve the sensitivity of graphene-based biosensors for DNA recognition and investigates an effect of copper foil oxidation on the growth graphene.
Highlights
Graphene, a kind of 2D material, has attracted great attention since it was first peeled off in 2004 from graphite via mechanical exfoliation method [1]
Our research provides an efficient method to improve the sensitivity of graphene-based biosensors for deoxyribonucleic acid (DNA) recognition and investigates an effect of copper foil oxidation on the growth graphene
The first piece of copper was left untreated; the second piece was soaked in 0.05 mol/L ammonium persulfate solution for 3 min, sonicated in deionized water for 5 min followed by blown with a nitrogen gun to remove the deionized water left on it; the third piece was soaked in a 0.05 mol/L acetic acid solution for 3 min, proceeded the subsequent process with the second copper foil
Summary
A kind of 2D material, has attracted great attention since it was first peeled off in 2004 from graphite via mechanical exfoliation method [1]. Several kinds of graphene have already been fabricated as important sensing materials to make label-free sensors for the detection of DNA, including mechanically exfoliated graphene [23,24], graphene oxide (GO) [25,26] and chemical vapor deposition (CVD) graphene [27,28,29,30]. Song et al [31] pre-treated the copper foil surface by chemical polishing to study the conditions for the growth of high-quality graphene. Cu copper foil with pre-H2 annealing and nitric acid treatment They synthesized high quality and uniform graphene on Cu by this method which can effectively reduce the impurities on Cu. Raman mapping results showed that 98.3% of the mapped area exhibited monolayer characteristics with I2D /IG. The Hall effect biosensor possesses an excellent sensitivity and specificity, which can effectively distinguish complementary target DNA from one-base mismatched DNA
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
