Abstract
The regional cerebral blood flow (rCBF) and the cerebral vasoreactivity of the patients with depressive disorder were observed by SPECT and acetazolamide stress SPECT test respectively. Eighteen unmedicated depressed patients and nineteen healthy control subjects were included. Baseline SPECT was performed in both patients and control subjects. Acetazolamide stress SPECT test was performed two days later in patients two hours after taking 2g acetazolamide orally. It was found that there was significant difference between the untreated depressed patients and the controls, because there was relatively reduced perfusion in frontal lobe, temporal lobe, left parietal lobe and right basal ganglia in depressed patients. After acetazolamide stress SPECT test, the perfusion of decreased regions in baseline step was increased. No potential ischemic lesion was found. The perfusion of some specific regions of the depressed patients decreased. Acetazolamide stress SPECT test could not reveal silent brain ischemia in the depressed patients. The perfusion of decreased regions in the baseline imaging was increased in acetazolamide stress SPECT test.
Highlights
According to some clinical researches in recent years, the patients with depressive disorder might have asymmetry cerebral artery dysfunction [1, 2] and abnormality of regional cerebral blood flow (rCBF) [3, 4]
The basal ganglia and cerebellum was outlined at the slices which best passed through the middle of the basal ganglia and cerebellum, and the mean SPECT value from these region were used as the relative measure of basal ganglia and cerebellar rCBF
Recent investigations on the cerebral blood flow of the depressive patients showed that the rCBF of some patients decreases, namely the rCBF low perfusion in frontal lobe and temporal lobe [3, 5]
Summary
According to some clinical researches in recent years, the patients with depressive disorder might have asymmetry cerebral artery dysfunction [1, 2] and abnormality of rCBF [3, 4]. The clinical significance and the mechanism was not clear. Its role and meaning in the occurrence and the development of the depressive disorder should be further investigated. RCBF of un-medicated patients was analyzed semi-quantitively using SPECT combined with Acetazolamide Stress Test (diamox test). The adjustment ability of the cerebral blood vessels of the patients in the region with decreased blood flow was observed and whether there is potential ischemic lesion was studied
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