Acetazolamide plus furosemide for periventricular dilatation: lessons for drug therapy in children

Abstract

Despite significant decreases in mortality for preterm infants attributable to technological and pharmacological advances in perinatal care, the rates of neuro-developmental impairment have been static. 1 Hack M Klein N Taylor HG Long term developmental outcome of low birthweight infants. Palo Alto, California: Packard Foundation. The Future of Children. 1995; 5: 176-196 Crossref PubMed Scopus (504) Google Scholar The major determinants of brain injury among preterm infants are severe periventricular haemorrhage with its associated complications, periventricular infarction and post-haemorrhagic hydrocephalus, and periventricular leucomalacia. Risk of congenital anomalies near hazardous-waste landfill sites in Europe: the EUROHAZCON studyThis study shows a raised risk of congenital anomaly in babies whose mothers live close to landfill sites that handle hazardous chemical wastes, although there is a need for further investigation of whether the association of raised risk of congenital anomaly and residence near landfill sites is a causal one. Apparent differences between malformation subgroups should be interpreted cautiously. Full-Text PDF