Acetals of lactams and acid amides. XV. Reaction of acetals of N, N-dimethyl- and N-methyl-N-(?-carbethoxyethyl)acetamides with ethyl anthranilate and synthesis of 4-quinolone and 4-quinazolone derivatives

Abstract

N, N-Dimethyl- and N-methyl-N-(β-carbethoxyethyl)-N1-(o-carbethoxyphenyl) acetamidines were synthesized by reaction of diethylacetals of N, N-dimethyl- and N-methyl-N-(β-carbethoxyethyl) acetamides with ethyl anthranilate. The thermal cyclization of these amidines proceeds in different ways — 2-dimethylamino-4-quinolone is formed in the first case, and 2, 3-dimethyl-4-quinazolone is formed in the second.