Acellular graft modified with bioactive peptides faster wound healing and tissue remodelling

Abstract

Decellualrized acellular matrix are enriched with Extracellular matrix (ECM) proteins and provides three dimenisonal (3D) biomimetic ultrastructure for tissue regeneration and remodelling. However, acellular matrix are potential used as inexpensive grafts there need to be modified with other growth factors or biomolecules such as silk protein, eggshell membrane protein, vitamines to overcome the loss of biomolecules during their fabrication. Soya protein (SP) is natural green component isolated with plant source and their derivative are biocompatible, non-inflammatory. Therefore, we studied the synergistic effect of the SP along with acellular matrix and modified the acellular matrix with SP by simple dip method without any crosslinking agents. The study outcome reveled that the after incorporation of SP, the anti-inflammatory, anti-microbial activity and biocompatbilty of the acellular martix signifcantly increased. Thus, this synergitic approache to design SP-acellular matrix could be a potential grafts for enhanced tissue regeneration or remodeling of chronic infections.