Abstract
Sixteen clinically healthy New Zealand white rabbits of either sex were divided into 2 equal groups (I and II) of 8 animals each. Under thiopental sodium (2.5%) anaesthesia a 2 x 3 cm full-thickness abdominal wall defect in the mid-ventral abdominal wall was created and repaired with an acellular dermal graft (ADG) in all the animals of group I (test group). In animals of group II (control group) a full-thickness linear midline abdominal muscular wall incision was made and repaired with a continuous suture pattern using 2-0 nylon.
Highlights
Defects of the abdominal wall continue to be a significant problem for patients and surgeons
A significant reduction in rectal temperature was observed in both groups of animals
Mild exudation at the site was noticed up to day 3 in group I, whereas no exudation was seen in the control group
Summary
Defects of the abdominal wall continue to be a significant problem for patients and surgeons. Common biological materials like small intestine mucosa[9], tensor fascia lata and lattisimus dorsi muscle[6], human dura mater[41], porcine dermal collagen[12], diaphragm[21,45], autologous full-thickness skin and dermis[4] have been used with limitations such as inflammatory oedema, adhesion formation and recurrence. The histocompatibility antigens present in cells generally lead to immunological reactions. Acellular dermal grafts have been used successfully in repairing septal perforations in humans[22]. Gulati and Cole[16] observed less immune response and better tolerance of acellular grafts in rats and rabbits. The present study was undertaken to evaluate acellular dermal grafting for the repair of abdominal wall defects in rabbits
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