Acellular Amniotic Membrane Patch Regeneration for Burn Injury: The Future for Wound Healing

Tayná Dias,Luiz Claudio Sobrinho Do Nascimento,Kalyane Machado,Ricardo Cunha,Maria Elisa Brum Do Nascimento,Kátia Renata Antunes Kochla,Péricles Varella Gomes,Marco André Cardoso,Vinicius Coneglian Santos,Rossana Baggio Simeoni,Alessandro Brawerman,Julio Cesar Francisco,Luiz Cesar Guarita-Souza

doi:10.4236/jbise.2019.128032

Abstract

Acellular amniotic membrane (AAM) is a biodegradable and biocompatible natural that has a wide range of applications in the field of pharmaceutics, biomedical, chemical and cosmetics industry. One of the most interesting characteristics of AAM is its antibacterial and anti-inflammatory, anti-angiogenic, anti-fibrosis activity is an attractive approach for treating inflammatory disorders, wounds, and burns. The isolated use of AAM may not be sufficient to produce an adequate anti-inflammatory and antimicrobial effect to fulfill different purposes, has attracted considerable attention that has similar properties to the native tissues. This mini-review offers a focuses on modern aspects of the biomaterials, growth factors, biocompatibility, and acellular matrix which are the basic elements for use in the tissue regeneration and replacement after an injury.

Highlights

The incidence of people with burns has been an increase progressively over the last decades, and it is estimated that more than one 1.2 million people die each year from burn in the USA [1]
The acellular amniotic membrane (AAM) a new strategy for tissue regeneration, due to its good biocompatibility and biodegradability and the majority are discarded with the placenta after parturiency [4]
This mini-review focuses on modern aspects of the biomaterials, growth factors, biocompatibility, and acellular matrix are the basic elements for use in the tissue regeneration and replacement after an injury

Summary

INTRODUCTION

The incidence of people with burns has been an increase progressively over the last decades, and it is estimated that more than one 1.2 million people die each year from burn in the USA [1]. 1 million people are diagnosed with burns per year, and 100.000 patients sought inpatient and, of these, about 2.500 patients will die directly or indirectly as a result of his burns in Brazil [2]. The acellular amniotic membrane (AAM) a new strategy for tissue regeneration, due to its good biocompatibility and biodegradability and the majority are discarded with the placenta after parturiency [4]. This mini-review focuses on modern aspects of the biomaterials, growth factors, biocompatibility, and acellular matrix are the basic elements for use in the tissue regeneration and replacement after an injury

SKIN NORMAL ANATOMY

BURN INJURY

CLINICAL USES OF AMNIOTIC MEMBRANE IN WOUNDS

FINAL CONCLUSION AND FUTURE PERSPECTIVES