Abstract
A newly-discovered angiotensin-converting enzyme 2 (ACE2) is a monocarboxy peptidase capable of metabolizing angiotensin (Ang) II to produce Ang-(1-7), which has been shown to exert vasodilatory/antiprofibrotic effects via its Mas receptor. In this work, we examined the impact of human recombinant ACE2 (hrACE2) on Ang II effects in cultured cardiomyocytes. Adult murine left ventricular cardiomyocytes were isolated and cultured. The Mas receptor antagonist A779 (10μM) and hrACE2 (0.2 or 2mg/mL) were added to the cardiomyocytes for 2h and 30min prior to 30-min exposure of Ang II (100nM), respectively.
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