Abstract
Treatment of hypertension with beta blockers or thiazide diuretics reduces the risk of stroke more than that of myocardial infarction [1, 2]. This may be due in part to adverse effects of these drugs on serum lipids and insulin resistance ‐ both independent risk factors for cardiovascular disease. Newer antihypertensive agents with neutral or beneficial effects on these parameters may offer greater protection against atheromatous vascular disease, particularly in high-risk groups such as patients with non-insulindependent diabetes mellitus (NIDDM) where hypertension, dyslipidaemia and insulin resistance often coexist. Interest has focused on angiotensin converting enzyme inhibitors (ACEI) because of mounting evidence that they may improve impaired vascular endothelial function, an early surrogate marker of atheroma.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
