Abstract
Sarcoidosis is a granulomatous disorder of unknown cause that most commonly involves the lungs, but which may affect virtually any organ in the body. The diagnosis of sarcoidosis is based on recognition of compatible clinical and radiologic features, demonstration of non-necrotizing granulomatous inflammation in the lungs or other affected tissues, and exclusion of alternative causes of granulomatous disease. 1 Crouser ED Maier LA Wilson KC et al. Diagnosis and detection of sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020; 201: e26-e51 Crossref PubMed Google Scholar However, because the clinical, radiological, and pathologic features of sarcoidosis overlap with those of multiple other disorders, achieving a secure diagnosis can be challenging. For this reason, clinicians have long sought a biomarker of sarcoidosis that would be both sensitive and specific for the disease.
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