Abstract
BackgroundThe Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1). AimTo investigate the association of ACE I/D polymorphism and Chronic Kidney Disease (CKD) in south India. MethodsIn the present study, we have collected CKD patients (n=147) and control subjects (n=211) from Tamilnadu. Genotyping was carried out by polymerase chain reaction (PCR) on the basis of allele specific primers. ResultsThe DD genotype is associated with the female population (OR-CI=2.40 (1.05–5.51), p=0.04) as compared to the male population (OR-CI=0.75 (0.37–1.51), p=0.42). Further, we found the over representation of “I” – allele (homozygous II and heterozygous ID) in unaffected males [OR (CI) – 0.58 (0.32–1.04), p=0.07] which suggests its protective role in male population. ConclusionThe DD genotype of ACE is associated with CKD in south India.
Highlights
Peer review under responsibility of Ain Shams University.Chronic Kidney Disease (CKD) is an International public health problem which is encompassing large phenotypes
The DD genotype of angiotensin converting enzyme (ACE) is associated with CKD in south India
Hypertension and diabetes are the major causes for CKD and it is common among different populations viz. African American, Hispanic, Asian American and Indian [5,6]
Summary
Peer review under responsibility of Ain Shams University. Chronic Kidney Disease (CKD) is an International public health problem which is encompassing large phenotypes. Each phenotype is the combination of an underlying kidney disease and superimposing environmental and genetic factors. The disease pathogenesis of renal failure is well correlated with genetic variability [1]; these findings highlight the importance of renal disease and its complications. Hypertension and CKD are closely associated diseases [2] which show several clinical complications like elevated blood pressure, poor renal outcome via pressure natriuresis mechanism [3,4]. The Renin-Angiotensin System (RAS) is an important regulator for blood pressure and kidney disease. The level of vaso active peptide Angiotensin-II is mainly determined by the RAS enzyme angiotensin converting enzyme-1 (ACE-1)
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