Abstract
We compared the accuracy of magnetic resonance imaging (MRI) measurements of pulsatile flow velocity in a small tube phantom using different spatial factors versus those obtained by intraluminal Doppler guidewire examination (as reference). We generated pulsatile flow velocities averaging about 20-290 cm/sec in a tube of 4 mm diameter; we performed phase-contrast cine MRI on pixels measuring 1.00(2)-2.50(2) mm(2). We quantified spatial peak flow velocities of a single pixel and a cluster of five pixels and spatial mean velocities within regions of interest enclosing the entire lumen in the phantom's cross-section. Finally, we compared the measurements of temporally mean and maximum flow velocity with the Doppler measurements. Linear correlation was excellent between both measurements of spatial peak flow velocities in one pixel. The highest spatial resolution using spatial peak flow velocities of a single pixel allowed the most accurate MRI measurements of both temporally mean and maximum pulsatile flow velocity (r = 0.97 and 0.99, respectively: MRI measurement = 0.95x + 8.9 and 0.88x + 24.0 cm/s, respectively). Otherwise, MRI measurements were significantly underestimated at lower spatial resolutions. High spatial resolution allowed accurate MRI measurement of temporally mean and maximum pulsatile flow velocity at spatial peak velocities of one pixel.
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