Abstract

The accuracy of continuous glucose monitoring (CGM) sensors may be significantly impacted by exercise. We evaluated the impact of three different types of exercise on the accuracy of the Dexcom G6 sensor. Twenty-four adults with type 1 diabetes on multiple daily injections wore a G6 sensor. Participants were randomized to aerobic, resistance, or high intensity interval training (HIIT) exercise. Each participant completed two in-clinic 30-min exercise sessions. The sensors were applied on average 5.3 days prior to the in-clinic visits (range 0.6–9.9). Capillary blood glucose (CBG) measurements with a Contour Next meter were performed before and after exercise as well as every 10 min during exercise. No CGM calibrations were performed. The median absolute relative difference (MARD) and median relative difference (MRD) of the CGM as compared with the reference CBG did not differ significantly from the start of exercise to the end exercise across all exercise types (ranges for aerobic MARD: 8.9 to 13.9% and MRD: −6.4 to 0.5%, resistance MARD: 7.7 to 14.5% and MRD: −8.3 to −2.9%, HIIT MARD: 12.1 to 16.8% and MRD: −14.3 to −9.1%). The accuracy of the no-calibration Dexcom G6 CGM was not significantly impacted by aerobic, resistance, or HIIT exercise.

Highlights

  • Regular physical activity can help people with type 1 diabetes improve glycemic control, decrease total daily insulin needs, achieve a healthier body mass index, and reduce risk of cardiovascular and peripheral neuropathy complications [1,2,3]

  • Physician’s recommendations were used to improve and compare the performance of an artificial-intelligence-based decision support algorithm as previously published [35]. This clinical trial was approved by the Institutional Review Board at Oregon Health & Science University (OHSU) on 9 March 2018, and additional information can be found at https:

  • Eight persons were randomly assigned to each exercise group for a total of 48 exercise visits and 16 sessions per exercise type

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Summary

Introduction

Regular physical activity can help people with type 1 diabetes improve glycemic control, decrease total daily insulin needs, achieve a healthier body mass index, and reduce risk of cardiovascular and peripheral neuropathy complications [1,2,3]. Despite these benefits, many people living with type 1 diabetes do not engage in the recommended amount of physical activity [4]. For example, is known to cause sharp drops in glucose levels [6,7].

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