Abstract
BackgroundChronic liver disease (CLD) is an important cause of morbidity and mortality and can lead to hepatic fibrosis. This study was conducted to evaluate the diagnostic value of real-time shear wave elastography (SWE) in the assessment of hepatic fibrosis.MethodsA systematic search of databases was performed for publications on SWE during the period between 2010 and 2017. The identified studies were analyzed using Meta-disc 1.4 software to integrate and analyze the data.ResultsEleven studies comprising 1560 patients were included for analysis. The pooled sensitivity, specificity and diagnostic odds ratio were 0.85 (95% CI: 0.82–0.87), 0.79 (95% CI: 0.76–0.82) and 30.81 (95% CI: 16.55–57.34), respectively for patients with a Metavir-score of ≥ F2; 0.87 (95% CI: 0.84–0.91), 0.84 (95% CI: 0.82–0.87), 41.45 (95% CI:18.25–94.45), respectively for patients with ≥ F3; 0.88(95% CI: 0.83–0.91), 0.91 (95% CI: 0.89–0.92), 67.18 (95% CI:30.02–150.31), respectively for patients with ≥ F4. The areas under the receiver operating characteristic curve of the three groups were 0.9147, 0.9223 and 0.9520, respectively.ConclusionsOur work demonstrates that SWE is highly accurate for detecting and staging hepatic fibrosis.
Highlights
Chronic liver disease (CLD) is an important cause of morbidity and mortality and can lead to hepatic fibrosis
The pooled sensitivity, specificity and diagnostic odds ratio were 0.85, 0.79 and 30.81, respectively for patients with a Metavir-score of ≥ F2; 0.87, 0.84, 41.45, respectively for patients with ≥ F3; 0.88(95% Confidence interval (CI): 0.83–0.91), 0.91, 67.18, respectively for patients with ≥ F4
Our work demonstrates that shear wave elastography (SWE) is highly accurate for detecting and staging hepatic fibrosis
Summary
Chronic liver disease (CLD) is an important cause of morbidity and mortality and can lead to hepatic fibrosis. Chronic liver disease (CLD) is an important cause of morbidity and mortality and can lead to hepatic fibrosis, cirrhosis, portal hypertension, and hepatocellular carcinoma. During the course of CLD, the death and inflammation of hepatocytes can lead to excessive deposition of extracellular matrix and abnormal distribution, resulting in hepatic fibrosis and its complications. This would eventually develop into cirrhosis [1]. The causes of this condition include the infection with hepatitis viruses, compromised autoimmune response, poisoning and metabolic damage.
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