Abstract
Background Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive. They are increasingly used in clinical settings in patients with movement disorders; however, the wide variety of systems available makes results conflicting. Research Question The objective of this study was to determine whether a markerless 3D motion capture system is a useful instrument to objectively differentiate between PD patients with DBS in On and Off states and controls and its correlation with the evaluation by means of MDS-UPDRS. Methods Six PD patients who underwent deep brain stimulation (DBS) bilaterally in the subthalamic nucleus were evaluated using BME and the Unified Parkinson's Disease Rating Scale (UPDRS-III) with DBS turned On and Off. BME of 16 different movements in six controls paired by age and sex was compared with that in PD patients with DBS in On and Off states. Results A better performance in the BME was correlated with a lower UPDRS-III score. There was no statistically significant difference between patients in Off and On states of DBS regarding BME. However, some items such as left shoulder flexion (p=0.038), right shoulder rotation (p=0.011), and left trunk rotation (p=0.023) were different between Off patients and healthy controls. Significance Kinematic data obtained with this markerless system could contribute to discriminate between PD patients and healthy controls. This emerging technology may help to clinically evaluate PD patients more objectively.
Highlights
Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive. ey are increasingly used in clinical settings in patients with movement disorders; the wide variety of systems available makes results conflicting
We showed that a markerless 3D system correlated with UPDRS-III scores. e utility of markerless techniques in the evaluation of movement disorders in a clinical setting is controversial because analysis parameters have not been standardized yet
Even though the DARI system has not been used for neurological movement disorders, including PD, we believe that the previous publications, which acquired data from healthy subjects, confirm its validity [4]
Summary
Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive. ey are increasingly used in clinical settings in patients with movement disorders; the wide variety of systems available makes results conflicting. Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive. E objective of this study was to determine whether a markerless 3D motion capture system is a useful instrument to objectively differentiate between PD patients with DBS in On and Off states and controls and its correlation with the evaluation by means of MDS-UPDRS. Ere was no statistically significant difference between patients in Off and On states of DBS regarding BME. Some items such as left shoulder flexion (p 0.038), right shoulder rotation (p 0.011), and left trunk rotation (p 0.023) were different between Off patients and healthy controls. Kinematic data obtained with this markerless system could contribute to discriminate between PD patients and healthy controls. is emerging technology may help to clinically evaluate PD patients more objectively
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
