Abstract
BackgroundThis study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome.Methods183 people referred for outpatient care at the Metabolism Unit of Hospital de Clínicas de Porto Alegre were evaluated with anthropometric, blood pressure, lipid profile, and adiponectin measurements. Glucose tolerance status was determined by 2-h 75-g oral glucose tolerance test and glycosylated hemoglobin. Definition of metabolic syndrome was based on the Joint Interim Statement of different medical associations. Twenty-one indices of insulin resistance were estimated from published equations. The accuracy of these indices was determined by area under the ROC curve (AUC) analysis. In addition, we determined an optimal cut point for each index and its performance as a diagnostic test.ResultsThe study population was comprised of 183 people (73.2% women; 78.7% white; age 52.6 ± 12.0 years, mean ± standard deviation), of whom 140 (76.5%) had metabolic syndrome. The reciprocal of the Gutt index provided the greatest AUC for identification of metabolic syndrome, but there were no statistical differences between Gutt and 11 AUC indices. Gutt presented 86.4% sensitivity and 76.7% specificity to identify metabolic syndrome.ConclusionsA number of commonly employed indices of insulin resistance are capable of identifying individuals with the metabolic syndrome.
Highlights
This study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome
Insulin resistance is associated with the development of the metabolic syndrome [2], which represents a cluster of cardiometabolic risk factors which promote the development of cardiovascular disease and type 2 diabetes [3, 4]
To investigate the relationship between insulin resistance and metabolic syndrome, we evaluated the correlation between multiple surrogate indices of insulin resistance and the presence of metabolic syndrome in adult participants, aged 24–83 years, with different degrees of glucose tolerance
Summary
This study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome. Insulin resistance is used to refer to the inability of insulin to stimulate glucose disposal [1]. Insulin resistance is associated with the development of the metabolic syndrome [2], which represents a cluster of cardiometabolic risk factors which promote the development of cardiovascular disease and type 2 diabetes [3, 4]. Antoniolli et al Diabetol Metab Syndr (2018) 10:65 under steady-state conditions in vivo [7]. It involves intravenous infusion of insulin, frequent blood sampling over a 2-h period, and continuous adjustment of a glucose infusion, making it an impractical tool for large-scale epidemiological studies and clinical practice [8]
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