Accuracy of deadspace free ventilatory measurements for lung function testing in ventilated newborns: a simulation study.

Abstract

A deadspace free method based on simultaneous ventilatory measurements in the inspiratory and expiratory limb of the ventilator circuit was compared to the conventional endotracheal method where the flow is measured between ETT and Y-Piece. The aim of our study was to find out how the arrangement of this setup affects the measuring accuracy of 1) the ventilatory and 2) the lung mechanical parameters by means of a computer simulation. The system consisting of ventilator tubes and lung was described in state space and the flow signals of endotracheal method, of deadspace free method and the pressure at the Y-piece were simulated in the time domain. To investigate the influence of the position of the pneumotachographs (PNTs) in the ventilator circuit on measuring accuracy, the distance d0 of the PNT from the Y-piece was varied between 0 and 900 mm. The respiratory compliance C, resistance R and inertance I were calculated by least square method using the simulated flow and pressure signals of both methods. Compared to the endotracheal method, with increasing d0, the tidal volume measured with the deadspace free method rose linearly, depending on the ratio between the compliance of the ventilator tubes to the respiratory compliance. The differences of C and R for both methods were acceptable (< 10%) if the distance between each PNT and the y-piece didn't exceed 200 mm and the shorter do the higher the measuring accuracy. The inertance could not be measured by this method with satisfactory accuracy if d0 was higher than 100 mm. The dead space free method can be used for accurate ventilatory measurements during mechanical ventilation. However, for lung mechanic measurements in very low birth weight infants the position of the PNTs must be as short as possible.