Accuracy evaluation of K and L XRF lead in bone (tibia) measurement by simulation with the specific purpose Monte Carlo code NCSXRF

Abstract

Lead poisoning in humans has become of increasing interest to medical researchers in the last few years-leading to the development of in vivo X-ray fluorescence (XRF) methods of analysis. These methods suffer from larger minimum detectable concentrations (MDC) than desirable. Monte Carlo simulation is capable of providing an easier and more efficient method of investigating possible improvements in the MDC and accuracy of XRF measurement in bone through the design optimization of XRF systems. The specific purpose Monte Carlo code NCSXRF has been revised to simulate hypothesized XRF systems that measure K X rays or L X rays of lead in tibia. Preliminary results demonstrate the capability of the revised NCSXRF code in the optimization of K and L XRF measurements of lead in tibia.