Abstract
Background Previous studies have shown that T1rho-weighted imaging using long spin locking pulses enables high discrimination between infarct and myocardium without the need for exogenous contrast agents. To optimize imaging protocols, it’s beneficial to understand the factors that influence the measurement. We measured the accuracy and reproducibility of spin echo-spin lock (SESL) T1rho-prepared balanced-steady-state free precession (bSSFP) sequences for myocardial relaxation time mapping. We subsequently performed in vivo studies and determined the average T1rho values in normal myocardium.
Highlights
Previous studies have shown that T1rho-weighted imaging using long spin locking pulses enables high discrimination between infarct and myocardium without the need for exogenous contrast agents
A phantom containing 8 homogeneous H2O cylinders with MnCl2 concentrations of 0.01- 0.15 g/mL was used for the comparison of 24 T1rho mapping sequences with various repetition times (TR = 1.8-10 sec), flip angles (0-70 degrees), and numbers of segments (Nseg = 10-70)
The scans were performed on a 1.5 T MRI (Avanto model, Siemens), and reference T1rho measurements were obtained by using gradient echo acquisition with TR = 10 sec, flip angle = 90 degrees, Nseg = 1
Summary
Previous studies have shown that T1rho-weighted imaging using long spin locking pulses enables high discrimination between infarct and myocardium without the need for exogenous contrast agents. It’s beneficial to understand the factors that influence the measurement. We measured the accuracy and reproducibility of spin echo-spin lock (SESL) T1rho-prepared balanced-steady-state free precession (bSSFP) sequences for myocardial relaxation time mapping. We subsequently performed in vivo studies and determined the average T1rho values in normal myocardium
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