Abstract
The uptake of methadone by the choroid plexus of rabbits fulfils the usual criteria for an active transport system. Methadone is taken up against an apparent concentration gradient and high concentrations of the narcotic can saturate the transport system. The uptake of methadone can be inhibited by low temperature, metabolic inhibitors, other narcotic drugs and narcotic antagonists. The transport system is competitively inhibited by morphine and verapamil. The transport system appears to have a higher affinity for methadone than for morphine. However, the system has about four times greater capacity to transport morphine than methadone. Calcium ions may somehow be involved with the narcotic transport system.
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