Abstract
A kinetic analysis of the rate of active (oxygen-dependent) accumulation of <i>p</i>-aminohippurate (PAH) by rabbit renal cortical slices was performed to confirm the existence of multiple renal organic anion transport systems. The kinetic analysis demonstrated the presence of two active uptake modes for PAH in this slice system. Acetate increased the rate of the oxygen-requiring component of each mode of PAH uptake by increasing the apparent V<sub>max</sub> of transport. Additional PAH transport modes were not revealed by the addition of acetate. These results were consistent with the hypothesis that more than one active transport system participates in the transport of organic anions in the renal proximal tubule cell.
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